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海外名师讲座

发布日期:2021-06-11

第一场:加拿大阿尔伯塔大学Lingyun Chen教授


讲座题目:一种基于羧甲基壳聚糖和纤维素纳米晶须的可控溶解自愈合水凝胶及其在二度烧伤治疗领域的应用

讲座形式:线上与线下相结合

讲座时间:20216159:00—10:00(线上)

报告会地点:2号楼三楼博学厅(线下)

 

报告人简介:

Lingyun Chen,博士,加拿大阿尔伯塔大学(University of Alberta)农业生命与环境科学学院教授、博士生导师,加拿大蛋白领域首席科学家。现为北美华人教授协会主席团成员、北美油化学学会蛋白质分会委员、国际谷物化学学会(AACCI)豆类分会委员、阿尔伯塔大学动物伦理委员会委员。2014年获聘为加拿大首席科学家荣誉称号(Canada Research Chair)。主要从事功能食品及生物材料产品研究与开发,在天然高分子构效关系,蛋白质与多糖水凝胶、纳米材料、药物靶向控制释放和伤口愈合材料有创新性研究,共发表学术论文100多篇,他人引用2000余次。

 

报告摘要:

因为伤口治疗时间冗长,烧伤面积大,形状不规则,深二度烧伤的治疗一直是医学领域的一个难题。目前临床治疗中,还没有一种办法既能减轻更换伤口敷料时病人的痛苦,同时避免伤口留下疤痕。针对这一难题,研制了一种能直接注射到无规则深度烧伤患处的自愈合水凝胶。这种水凝胶能基于伤口的具体形状,自动变形从而完全覆盖伤口,同时可以被氨基酸水溶液溶解,在给病人更换伤口敷料的时候,不需要强行将粘附在伤口上的敷料取下。这种水凝胶由羧甲基壳聚糖(CMC)和醛基修饰的纤维素纳米晶须(DACNC) 构建,通过氨基和醛基生成可逆的亚胺键,形成自愈合水凝胶。由于DACNC拥有大的纵横比和比表面积,它具有大量的活性基团,使得水凝胶在被破坏后可以快速的自我修复。另外,DACNC可以作为纳米增强填充剂,有助于提高凝胶的强度。细胞毒理研究和3D细胞包埋结果表明这种凝胶有非常好的生物相容性,并且可以作为细胞生长的体外基质。动物实验数据表明CMC/DACNC自愈合水凝胶可以有效加速深二度烧伤愈合和减少疤痕的形成。

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第二场:加拿大麦吉尔大学Yixiang Wang博士

 

讲座题目:Recycling of cellulosic wastes into functional materials

讲座形式:线上与线下相结合

讲座时间:202161510:00—11:00(线上)

报告会地点:2号楼三楼博学厅(线下)

 

报告人简介:

Dr. Yixiang Wang is an Assistant Professor in the Department of Food Science and Agricultural Chemistry at McGill University, Canada. Dr. Wang received his BSc in Chemistry and Doctoral degree in Polymer Chemistry and Physics from Wuhan University, China. Following a post-doctoral fellowship at University of Alberta, Dr. Wang worked there as a Research Associate from 2012 to 2017. Dr. Wang conducts research related to the fabrication of natural polymer based nano/micro particles, nano/micro fibers, composite films and hydrogels, and the understanding of relationship between molecular structure and functional properties. The overall aim is to explore a systematic approach to develop value-added applications of natural polymers in functional food and biodegradable materials. Dr. Wang has authored/co-authored 74 journal articles (h-index 26, i10-index 51, citations 2288), 4 book chapters, and 1 patent. He has been serving as reviewer for many leading journals in the fields of food, polymer, and materials.


报告摘要:

The amount of biomass wastes is rapidly increasing, which leads to numerous disposal problems and governance issues. Thus, the recycling and reuse of biomass wastes into value-added applications have attracted more and more attention. Waste paper is a major contributor to municipal and industrial waste, and its recycle and reuse are a current challenge. At the same time, more than 10 million tons of textile waste are disposed through landfill every year in North America. Therefore, based on the understanding of various structures, conformations and interactions, we aim to recycle cellulosic wastes into functional materials with desirable properties for food and agricultural applications.

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第三场:新加坡南洋理工大学Yonggui Gao教授

 

讲座题目:Understanding molecular mechanism of cellulose biosynthesis towards its application development

讲座形式:线上与线下相结合

讲座时间:202161511:00—12:00(线上)

报告会地点:2号楼三楼博学厅(线下)

 

报告人简介:

Yonggui Gao,博士,新加坡国立研究基金获得者,现为南洋理工大学生物科学学院终身副教授和新加坡科技研究局细胞分子研究所资深研究员, 专长为结构生物学和蛋白质化学。目前主要从事核糖体结构与功能,以核糖体为靶位的抗生素作用机理及新型药物的设计研究;以DNA/RNA修饰所引发的人类疾病(如肥胖基因FTO)相关基因的调控和拮抗剂的研制,以及细胞分泌多糖的生物学合成和开发利用等。已在Science, Cell, Nature Structural & Molecular BiologyPNAS等高水平杂志上发表多篇论文,其中多篇被杂志封面所报道, 包括Science, Cell, JBC, Chemical Sciences等。目前担任Scientific Reports 等杂志编委。

 

报告摘要:

As the most abundant biopolymer in Earth, cellulose has many potential industrial applications, such as the source of renewable energy. Cellulose is synthesized by the synthase of the Glycosyltransferase GT-2 family. In bacteria, the cellulose synthase (CESA) is composed of several hetetro-subunits that form a complex (also called terminal complex) to synthesize and extrude glucan chain. In land plants, cellulose is produced at the plasma membrane by six-lobed rosette-shaped CESA complexes (CSCs) where each CESA is thought to synthesize one cellulose chain. Bacterial cellulose is not essential. In contrast, plant cellulose is absolutely required, which is an essential component for cell wall formation. While plant cellulose’s biological functions are relatively well understood, molecular details of how cellulose is produced remain largely unknown. Very recently, atomic structural information has closed this gap to some extent, and greatly advanced our understanding of its biosynthesis. In this talk, we will be introducing these exciting progresses, in particular our structures of Arabidopsis thaliana CESA3, in apo and substrate UDP-glucose bound form.


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参会须知:
(1)应疫情防控需要,有意向者需点击下方二维码,报名参会。(2)参会人员必须严格遵守疫情防控相关规定,14天内无中高风险地区旅居史,进入线下会场请配合核查健康码,会议期间请全程佩戴口罩,隔位就座。(3)当天有发热、咳嗽、咽痛等症状的师生不得进入线下会场。







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